volume 165 number 2 March-April




Z. Tediashvili

Uniqueness in the Inverse Problems of the Potential Theory

Presented by Corr. Member of the Academy R.Bantsuri, June 26, 2001
Abstract. Inverse problems of the potential theory are considered for two-dimensional domains. The uniqueness theorems are proved within specific restrictions for boundaries of the domains and densities of potentials.

Key words: inverse problems, potential theory.




B. Dochviri, M. Shashiashvili

On Some New a Priori Estimates in the Theory of Variational
Inequalities via Stochastic Analysis

Presented by Member of the Academy I. Kiguradze, May 31, 2001

Abstract. This paper is devoted to the proof of new a priori estimates in the theory of variational inequalities (in particular for the obstacle problems) by the techniques of stochastic analysis. Namely, we essentially use the semimartingale inequalities for the Snell envelopes and the connection between optimal stopping problems and variational inequalities.

Key words: variational inequalities, Multidimensional diffusion processes, optimal stopping, Snell envelopes, semimartingales.




G. Sirbiladze, N. Zaporozhets

Choquet's Capacity of Order Two in the Murofushi-Sugeno's
Probability Representation of a Fuzzy Measure

Presented by Corr. Member of the Academy N. Vakhania, June 5, 2001

Abstract: In this paper, we consider T. Murofushi and M. Sugeno probability representation (MSPR) of a fuzzy measure on a finite set. The theorems of existence of Choquet's second order capacities in the MSPR are proved.

Some properties of a monotone expectation in relation to MSPR are also obtained.

Key words: Fuzzy measure, Probability representation of a fuzzy measure, Monotone expectation.



N. Toradze

On Certain Partial Sums of Haar Wavelet Expansions

Presented by Member of the Academy L. Zhizhiashvili, June 11, 2001

Abstract. There is given explicit representation of Dirichlet kernel with respect to Haar wavelet for certain partial sums. There are given some results about behaviour of corresponding Fourier expansions.

Key words: Haar wavelets, fourier coefficients, dirichlet kernel.




I. Dochviri

Diffusion Approximation in Palm's Model

Presented by Corr. Member of the Academy N. Vakhania, July 10, 2001

Abstract. The question of diffusion approximation of the number of faulty machines in the Palm's model is studied in the present paper.

Key words: queueing theory, Palm's model, normed queueing processes, diffusion approximation of the random processes.




A. Ebralidze

On the Convergence of Multiple Lacunary Trigonometric Series Almost Everywhere

Presented by Corr. Member of the Academy L. Zhizhiashvili, July 10, 2001

Abstract. Specific type convergence of multiple lacunary trigonometric series is studied.

Key words: multiple trigonometric series, lacunarity, almost everywhere convergence, rectangular sums.




M. Dzadzamia

On Equivariant Shape Retracts

Presented by Corr. Member of the Academy N. Berikashvili, July 10, 2001

Abstract. In this paper we study an equivariant shape theory and retracts of equivariant shape category of metric spaces with an action of given compact group G.

Key words: G-space, equivariant shape category, equivariant shape retract.



A. Danelia

Stochastic Variational Inequalities and a Priori Estimates for the Value Functions of the Optimal Stopping Problem

Presented by Corr. Member of the Academy N. Vakhania, July 3, 2001

Abstract. In the given work the new a priori estimates in the theory of stochastic variational inequalities have been obtained.

Key words: variational inequality, multidimensional diffusion process, Snell envelopes, semimartingales.




Z. Avaliani

Regular Elements of Complete Semigroups of Binary Relations Defined by Semilattices of the Class S1(X,5)

Presented by Corr. Member of the Academy D. Baladze, December 26, 2002

Abstract. Regular elements of the semigroups of binary relations defined by semilattices of the class S1(X,5) are completely described in the paper.

Key words: regular elements, binary relations, semilattices.




G. Japaridze

Preliminary Results on the Basic Predicate Logic of Racefree Games

Presented by Corr. Member of the Academy H. Inassaridze, December 4, 2001

Abstract. The semantics of parallel game combinations is refined and the corresponding predicate logic is fully axiomatized.

Key words: game logics, game semantics, linear logic.




G. Japaridze

Preliminary Results on the Basic Predicate Logic of Racefree Games

Presented by Corr. Member of the Academy H. Inassaridze, December 4, 2001

Abstract. The semantics of parallel game combinations is refined and the corresponding predicate logic is fully axiomatized.

Key words: game logics, game semantics, linear logic.




Z. Samkharadze

Hydrodynamic Problem with Account of the Coefficient of Hydraulic Resistance

Presented by Corr. Member of the Academy A. Prangishvili, August 10, 2001
Abstract. Solution of the hydrodynamic problem in pipelines is analyzed for the case, when the principle of alteration of lengthwise hydraulic resistance is known. Basing on the differential equations of motion the analytical solution is found permitting to define the pressure and velocity in any cross-section at a given moment.

Key word: pipeline, hydraulic resistance; pressure; velocity.




G. Berria

Specific Properties of the Ball Lightning

Presented by Corr. Member of the Academy T. Chelidze, October 3, 2000

Abstract. The ball lightning is the atmospheric anomalous phenomenon and the nature of its origin is not completely understood. The present paper is an attempt to solve some of the problems connected with the ball lightning by means of the theory of atmospheric universal stationary toruslike electric structure (AUSTES).

Key words: ball lightning, anomaly.




J. Mebonia, V. Jikia, G. Skhirtladze

Investigation of the Reaction He(e,2e)He+ by Three-Particle Approach

Presented by Corr. Member of the Academy A. Khelashvili, December 26, 2001

Abstract. Ionization of helium atom by electrons He(e,2e)He+ is studied in approximation of three-particle unitarity approach. Detailed calculations are fulfilled in asymmetric complanar geometry for different sets of kinematic parameters. Satisfactory explanation of experimental data is reached.

Key words: ionization, reaction, three-particle approach.




I. Metskhvarishvili

Investigation of the Internal Conversion Coefficients for the
169Tm 63.119keV g-Transition

Presented by Member of the Academy N. Amaglobeli, June 26, 2001

Abstract. The conversion spectrum of 169Tm 63.119keV g-transition has been measured by magnetic prism beta spectrometer. L1-, L2-, L3 conversion lines are divided. Their forms are studied and relative values of their spreadings are measured. Relative and absolute internal convertion coefficients of this g-transition are determined on the L1-, L2-, L3 subshells. Experimental results are compared with modern theoretical tables for their verification.

Key words: beta spectrometer, g-transition, conversion line.




T. Khazaradze

Belated Comment on "Feynman's Proof of the Maxwell Equations" by F. J. Dayson

Presented by Corr. Member of the Academy A. Khelashvili, June 12, 2001

Abstract. The substantiation of the complete set of the Maxwell equations and its connection with the nonrelativistic Newtonian equations of motion are discussed.

Key words: Maxwell equations, Feynman's proof, invariance.




T. Pagava, Z. Basheleishvili, M. Stamateli, E. Kutelia,
Member of the Academy G. Tsintsadze

Influence of Charge State of Frenkel Pairs on the Efficiency of the Formation of Radiation Defects in n-type Silicon Crystals

Presented June 12, 2001

Abstract. The effect of the electron flux density j on the efficiency h of the production of radiation defects in n-type silicon samples is investigated. It is shown that optimum correlation exists between the quantity of primary radiation defects and that of the free electrons charging them. The result of it is the maximum observed on h(j) curve, which location (along the j axis) depends on concentration of the free electrons.

Key words: silicon, radiation intensity, charge state, radiation defects (rd).




Z. Gabrichidze

On the Formation of Peaks Observed in the Range up to 300 cm-1 from Excited Resonance Line in Raman Scattering Spectra of Water, Saturated Water Solutions and Some Crystals with Hydrogen Bonds

Presented by Member of the Academy N.Tsintsadse, December 26, 2001

Abstract. Raman scattering spectra of some crystalhydrates, water and saturated water solutions of these crystals are obtained in the so-called low frequency range (0-300 cm-1). V.Sakun's quasicrystal model was used to understand the formation of the observed band in the excited spectra.

Key words: peaks, hydrogen bond.




N. Ograpishvili

Physical Conditions in Solar Active Regions at Different
Stages of Evolution

Presented by Corr. Member of the Academy R.Kiladze, December 26, 2001

Abstract. Physical characteristics of 4 flocculi were studied with the observational material obtained on the double spectroheliograph of the Crimean tower-type telescope. The areas and intensities of separate nodes of flocculi were evaluated. Consequently the values of temperatures and densities were calculated and compared to their theoretical curves.The detailed study of active regions indicates that new active regions are characterized by the temporal variation of the temperature, while old flocculi are characterized by the variation of the density.

Key words: active regions, flocculus.



K. Tavartkiladze, G. Mestiashvili, E. Sajaia, L. Beroshvili

On Estimation Method of Desertification Process

Presented by Corr.Member of the Academy Z.Tatashidze, June 19, 2001

Abstract. We have elaborated analytical estimation method of desertification using two parameters: soil surface temperature and precipitation. The criterion of estimation is determined based on the values of positive anomalies of soil surface temperature and negative anomalies of precipitation.

Key words: desertification, estimation method.




Corr. Member of the Academy R. Kiladze, M. Kachakhidze, V. Kukhianidze,
N. Kachakhidze, G. Ramishvili

Study of Relationships Between Astronomical Phenomena and Strong Earthquakes of the Caucasus by Fourier-analysis

Presented June 19, 2001

Abstract. The problem of the correlation of planets revolution periods and the frequencies of the origin of the earthquakes for the Caucasus has been considered. The obtained results enable us to make the following conclusion: the earthquakes more of all happen in the period of Moonrise i.e. during outflow (Moon tide). Besides, as it concerns the phases of the Moon, the earthquakes avoid the period from the waning half up to the new moon. In other periods earthquakes are distributed more or less evenly.

Key words: earthquakes, seismoactive region, moonrise.



O. Lursmanashvili, N. Kachakhidze

Searching of Connection between Earthquakes by Migration Waves for Seismoactive Regions of Turkey and Greece

Presented by Member of the Academy B. Balavadse, June 19, 2001

Abstract. The observed results of the detailed analysis of the recurrence of earthquakes in time and space in the neighboring seismoactive regions of Turkey and Greece enable us to make the following conclusion: in each seismoactive region considered by us, large earthquakes affect each other. The interrelation between earthquakes are accomplished through infra-low frequency waves of migration, which are excited during large earthquakes and characterized by the capacity of initiation and as a triggering factors favor initiation of the following earthquakes. Thus the chain-type relation is accomplished between earthquakes which proceeds by the observance of chronology of the subsequence of earthquakes appearance.

Key words: earthquake, seosmoactive, migration.

Organic Chemistry


Sh. Samsoniya, N. Mirziashvili

Synthesis of Some Derivatives of Dibenzofuran

Presented by Corr. Member of the Academy L. Khananashvili, June 12, 2001

Abstract. Three derivatives of dibenzofuran: 1H - Benzo[b]furo[3,2(2,3)-f]benztriazole, 2,1,3-Benzo[b]furo[2,3(3,2)-f]benzthiadiazole and 1H-Benzo[b]furo[3,2(2,3)-f]benzimidazole were synthesized and their structures were studied by IR-, UV-, PMR- and mass spectroscopy.

Key words: dibenzofuran, derivatives, synthesis.


Physical Chemistry


R. Tsanava, G. Bezarashvili, Z. Dzotsenidze, M. Katsitadze, R. Kobaladze,
G. Gaganidze, T. Rostomashvili

Simultaneous Action of Acetaldehyde and Carbon Tetrachloride on the Flame Propagation Process

Presented by Member of the Academy T. Andronikashvili, May 29, 2001

Abstract. The article is devoted to the experimental investigation of the simultaneous action of acetaldehyde and carbon tetrachloride on flame propagation in detonating mixture diluted with helium. The 2 - factoral mathematical design method was used and empirical regression equation was derived that provides good fit to experimental data. From the results obtained it might be concluded that investigated admixtures' simultaneous action on the combustion process is of additive character.

Key words: acetaldehyde, carbon tetrachloride, flame propagation, inhibition effect.


Physical Chemistry


M. Katsitadze, G. Bezarashvili, Z. Dzotsenidze, M. Abuladze,
R. Tsanava, R. Kobaladze

Study of Active Admixtures Action on the Inflammation Process of Detonating Mixtures

Presented by Member of the Academy T. Andronikashvili, May 29, 2001

Abstract. We have studied simultaneous action of acetone and acetaldehyde additives on the inflammation of detonating gas at low pressures. Mathematical design method was applied and empirical regression equations have been deduced. Experimental results show that inhibiting action of the investigated admixtures is of additive nature.

Key words: acetone, acetaldehyde, inflammation, mathematical design.



I. Gurgenidze, Corr. Member of the Academy J. Japaridze, Sh. Japaridze

Adsorption of Naphtalene at the Mercury/Ethylene Glycol Interface

Presented July 17, 2001

Abstract. The adsorption of naphtalene on a polarized Hg electrode from solution in ethylene glycol has been investigated by capacity measurements. The experimental data have shown that adsorption of naphtalene conforms well to a Frumkin isotherm with particle-particle interaction corresponding to attraction.

Key words: adsorption, naphtalene, ethylene glycol, capacity, isotherm, attraction.




R. Kvaratskhelia, E. Kvaratskhelia

The Role of Electrode Nature and Solution Composition in the Process of Electrohydrogenation of C ļ C Bond in Acetylenedicarboxylic Acid

Presented by Corr. Member of the Academy J.Japaridze, May 14, 2001

Abstract. Voltammetry of acetylenedicarboxylic acid at the electrodes from Cd, Cu, Ta, Cu-Hg and alloys of Cd with Sn, Cu, In, Ni, Hg, Ag in various aqueous solutions has been studied. The main kinetic parameters of the acid electrohydrogenation process have been determined. The influence of electrode nature and solution composition has been explained.

Key words: voltammetry, electrode, wave, reduction, hydrogenation, bond.


Pharmaceutical Chemistry


N. Tabatadze, L. Zviadadze, A. Favel, F. Delmas, C. Di Giorgio, G. Balansard,
Member of the Academy E. Kemertelidze

Biologically Active Triterpene Saponins from Cephalaria gigantea

Presented June 26, 2001

Abstract. Two monodesmosides, bioside of oleanolic acid and tetraoside of hederagenin were isolated from the roots of Cephalaria gigantea (Dipsacaceae) and identified as giganteosides D and E respectively. Their antifungal and antiprotozoal activities have been studied.

Key words: Cephalaria gigantea, Dipsacaceae, triterpene saponins, giganteoside, Trichomonas vaginalis, Leishmania infantum.


Physical Geography


R. Tolordava

To the Problem of Classification of State Borders

Presented by Corr. Member of the Academy A. Kiknadze, March 3, 2002

Abstract. Classification of the State borders stipulated the necessity to work out delimitation formula and the process of its local realization. Existing classifications are analyzed in the work and a structural diagram of classification of the border is given basing on the constituent parts of the State territory.

Key words: classification, border.




Sh. Jaoshvili

On Water Balance of the Black Sea

Presented by Corr. Member of the Academy Z. Tatashidze, June 5, 2001

Abstract. We consider the problems concerning the water balance of the Black Sea. According to the new data river discharge is determined on the basis of which component elements of water balance are adjusted.

Key words: the Black Sea, discharge, water balance, underground waters, evaporation, precipitation, sea level.




E. Abashidze

Karst and Water Supply Objects

Presented by Corr.Member of the Academy I.Buachidze, December 26, 2001

Abstract. The paper deals with a mathematical expression for preliminary estimation of the crack propagation in a definite time span at water velocity up to 1 cm/sec before the construction of reservoirs or some other objects in karst rocks and during their exploitation, i.e. quantitative method gives possibility to define productivity of the object, diagnose, forecast and define the quantitative volume of the phenomenon.

Key words: karst, carbonate rock, crack, speed of filtration.


Genetics and Selection


I. Kapanadze

Specificity of Oncogens and Their Heredity in Citrus Genus
(Citrus L.)

Presented by member of the Academy P. Naskidashvili, September18, 2001

Abstract. There are four categories of oncogens: medullar, xylem, phloem and epidermal. Oncogens are not subjected to heredity rules but still they have the tendency of transmission. The transmission of oncogens from one generation to another does not occur through the somatic nucellar cells. Oncogenic disease reaches its maximum when inbreeding oversteps the limit.

Key words: oncogen, inbreeding, transmission, neophyosis, nucellus.

Genetics and Selection


Sh. Sharia, L. Mzhavanadze

The Process of Meiosis in Persimmon Variations

Presented by Corr. Member of the Academy P. Naskhidashvili, May 8, 2001

Abstract. All the variations of Japanese persimmon (D. kaki L.) both fertile and sterile forms derive aneuploid sporocytes. Aneuploids are characterized by seedless fruit, high content of tannin and increase of fructification by 20-30%, rise of saccharinity by 30-50%. Aneuploids are derived from fertile as well as sterile forms. The aneuploid sterility is caused by the central and terminal inversions of the chromosomes, by formation of asynaptic sectors and loops. Moving to the poles the aneuploid chromosomes are segregated coming to elimination. Out of the whole complex of chromosomes of the persimmon only three of them show fluorescence ability with different intensity.

Key words: persimmon, aneuploidy, inversion, loop, fluorescence.


Human and Animal Physiology


Kh. Kuprashvili, R. Intskirveli, N. Mgaloblishvili, M. Chikovani,
Member of the Academy T. Ioseliani

Influence of Noradrenaline on the Seizure Activity Induced by
Hippocampal and Neocortical Electrical Stimulation

Presented June 12, 2001

Abstract. The acute experiments have been carried out in adult rabbits of either sex. Influences of direct application of noradrenaline on the neocortex and its intrahippocampal administration have been studied in the neocortical and hippocampal seizure reactions induced by electrical stimulation. It was found that noradrenaline affects in a different way the seizure reactions induced from different sources. Specifically, noradrenaline suppresses the hippocampal seizures and facilitates the neocortical ones.

Key words: seizures, hippocampus, neocortex, noradrenaline, rabbits.


Human and Animal Physiology


R. Kashakashvili

Long-Term Potentiation of the Cortical Dendritic Potentials

Presented by Member of the Academy T.Oniani, June 5, 2001

Abstract. In acute experiments in cats under deep nembutal anesthesia the long-lasting potentiation of cortical dendritic potentials was revealed. The potentiation elicited by direct brief tetanic stimulation of the cortex, lasted for several hours.

Key words: dendritic potentials, cortex, long-term potentiation.


Human and Animal Physiology

Member of the Academy M. Khananashvili, D. Tsintsadze, E. Kareli, E. Imnadze

Comparative Analysis of Amiridin and Plaferon Influence on the Psychogenic Stress in the Rats

Presented June 12, 2001

Abstract. Influence of amiridin and plaferon on the two-way avoidance conditional reflexes were studied in the adult albino rats. Original method of self-consumption of the drugs has been implemented.

Key words: amiridin, plaferon, stress, self-consumption, conditioned reflexes, rats.




D. Khachidze, Ya. Kalandadze, G. Majagaladze, Sh. Barbakadze, J. Monaselidze

Microcalorimetric Investigation of the DNase Influence on Nuclear Chromatin Domain Structure

Presented by Member of the Academy T. Beridze, June 5, 2001

Abstract. It has been shown that the process of unfolding and decay of high-ordered structures of nuclear chromatin, due to digestion by DNase I to the level of subnucleosomal core particles are not accompanied by any noticeable heat effect. It is supposed that the unfolding process of 30 nm solenoid structure has entropic nature. Fragments of 30 nm solenoid-fibre obtained due to digestion by DNase I are protected better than fragments of 10 nm fibre-filament.

Key words: DNase, nuclear chromatin, microcalorimeter, chromatin, subnucleosomal core particles.




T. Devdariani, T. Dolidze, V. Tabidze

Peptide Conjugates of Benz(a)Pyrene in Plants

Presented by Member of the Academy T. Beridze, December 28, 2001

Abstract. The metabolism of carcinogenic polycyclic aromatic hydrocarbon (PAH) _ 7,10-14C-benz(a)pyrene in seedlings of corn (Zea mays L.), pumpkin (Cucurbita pepo L.), bean (Phaseolus vulgaris L.), pea (Pisum sativum L.) was investigated. The BP is absorbed by plants through roots and then transported through stem to leaves. Part of BP is accumulated in vacuoles with inclusion of carbon radioactive atom in low molecular weight substances _ organic acids, amino acids, peptides of low molecular weight and proteins. The aromatic rings of part of BP are entirely destructed which specifies the isolation of radioactive carbon dioxide. The BP metabolites _ oxy-, dioxy- and quinone derivatives form conjugates with low molecular peptides. In BP-treated plants in comparison with control plants the content of low molecular weight peptides is increased.

Key words: carcinogenes, plants, radioactivity, metabolism, conjugates.



M. Betsiashvili, N. Kuprava, T. Sadunishvili,

Corr. Member of the Academy N. Nutsubidze

Study of the Georgian Soybean Varieties for Preparation of Valuable Food Protein

Presented June 12, 2001
Abstract. Protein fractions content, as well as protein spectrum of cultivated in Georgia soybean varieties have been studied. It has been stated that protein content in flour is the highest in the variety Kolkhuri. Besides, isoelectrofocusing of different protein fractions revealed that the difference in protein spectrum of studied varieties is little.

Suspensions of concentrated and purified albumin and globulin fractions from the variety Kolkhuri were mixed on water bath. The obtained thick, phorous protein coagulate, exposed stability against mechanical and thermal processing.

Key words: soybean varieties, protein spectrum, albumins and globulins, valuable food protein.



G. Zaalishvili, N. Surguladze, D. Margiani,

Corr. Member of the Academy T. Zaalishvili

Study of the Role of Proteolysis of Nuclear Matrix Poly(ADP-ribose) Polymerase in Sharp Decrease of the Enzyme Activity by X-irradiation of Rats

Presented June 26, 2001

Abstract. It has been shown that the decrease of poly(ADP-ribose) polymerase activity of the liver nuclear matrix isolated 30 min after 6.7 Gy X-irradiation of rats is not stipulated by proteolysis of poly(ADP-ribose) polymerase.

Key words: liver, nuclei, nuclear matrix, poly(ADP-ribose) polymerase.


Microbiology and Virology

Z. Lomtatidze, I. Gorozia, B. Lomsadze

Study of Lipids Formation in Streptomyces fulvissimus and its Morphological Variety

Presented by Corr. Member of the Academy D. Ugrekhelidze, May 28, 2001

Abstract. The intensity of lipids synthesis, qualitative constitution and growth peculiarities of neutral lipids in Streptomyces fulvissimus and its morphological variety have been investigated.

Key words: antibiotic producers, morphological variety, neutral lipid.


Microbiology and Virology

M. Jgenti, M. Samadashvili, N. Ramishvili, L. Mazanishvili

Importance of the Host Plant Variety and Geographical Origin of Nodule Bacteria Strains for the Efficiency of Inoculation

Presented by Member of the Academy T. Chanishvili, May 5, 2001

Abstract. The efficiency of bacterization with one industrial and several local strains of Rhisobium from the East and West Georgia were studied in pot and field experiments. Two varieties of Soybean (Glycine hispida Max.) from different geographical regions were inoculated. Bacterization caused increasing of the number of nodules, pods, plant height, beans weight. Also the amount of free amino acids in stem and leaves increased. Strains from the West Georgia were more effective, than the strains from the East Georgia.

Key words: host plant, Rhisobium strains, bacterization.


M. Murvanidze

Zoogeographical Distribution of Oribatid Mites (Acari: oribatei) of Tbilisi

Presented by Corr. Member of the Academy B. Kurashvili, July 24, 2001

Abstract. Zoogeographical distribution of oribatid mites of Tbilisi is discussed. The list of oribatid mites through their zoogeographical belongness is given.

Key words: zoogeographical distribution, oribatid fauna.



M. Bregadze

Action of Magnetic Curative Compounds on Animal's Brain and Peripheral Blood

Presented by Member of the academy T. Oniani, May 31, 2001

Abstract. The action of nonmagnetic and magnetic curative pharmacological and traditional compounds was studied in dynamics for 30-40 days on the quantitative and morphological changes in the brain and peripheral blood cells of guinea pigs exposed to nonmagnetic and 300 Ersted constant magnetic field (CMF).

In guinea pigs not exposed and exposed to magnetic field magnetized water solution (valerian, caffeine) and hormonal (prednisolone) preparations, as well as herbal extracts have a positive effect on the brain and blood cells. In the magnetic field of the exposed experimental and control animals the brain and blood cell damage-recovery difference reveals the bioactivity and curative properties of herbal compounds.

Key words: constant magnetic field (CMF), brain cell, peripheral blood cells.



M. Ebelashvili, N. Kuprava, K. Chkhikvadze, G. Zaalishvili

Influence of Nitrobenzene Different Concentrations on Ultrastructure of Maize Root Tip Cells

Presented by Member of the Academy G. Kvesitadze, June 19, 2001

Abstract. The effect of different concentrations of nitrobenzene on maize root tip cells ultrastructure has been studied. It has been demonstrated that nitrobenzene concentrations up to 0.015mM are harmless for plant cells, as they do not cause noticeable changes of cell ultrastructure. Higher concentrations of nitrobenzene 0.15mM lead to significant ultrastructural changes, up to the complete destruction of a cell.

Key words: nitrobenzene, maize roots, cell ultrastructure.



E. Mishatkina, E. Cherkezia, M. Gogoladze,

Corr. Member of the Academy G. Tumanishvili, P. Tchelidze

Distribution of Different Functional Groups of Cells Throughout the Functional Segments in Proximal Tubule of Normal Rat Kidney

Presented May 15, 2001
Abstract. The 3-D reconstruction of different functional segments of proximal tubule of normal rat kidney has been made. We managed to show the distribution of different functional groups of cells throughout S1 and S2 segments of proximal tubule.

Key words: 3-D reconstruction, renal tissue, proximal tubule, stereologic study.



N. Chipashvili, M. Mamaladze

Myelin Fibers of Dental Pulp and their Partial Demyelination under Acute Pulpitis

Presented by Member of the Academy T. Chanishvili, December 25, 2001

Abstract. We have studied myelin fibers in norm and in teeth pulp with acute pulpitis and made comparative characteristics. This helps to imagine the innervation of the tooth better and to understand the mechanism of pain syndrome onset. The analysis of the obtained data from the viewpoint of functional possibilities of myelin fibers shows that conduction of impulses along them must be different for norm and clinical material. Due to the disorder of fiber wholeness the passive permeability for Na+ions increases and this leads to the change of membrane polarization.

Key words: pulpitis, myelin fiber.



I. Lejava, I. Kavadze, D. Tatulashvili, G. Sukoian, A. Melia,

Corr. Member of the Academy N. Karsanov

Effects of direct action antihypoxant and antioxidant Energostimon lipid profiles in patients with ischemic heart disease

Presented December 26, 2001

Abstract. The primary endpoint of the trial is efficacy of Energostimtreatment on the deteriorations in lipid profiles in patients with ischemic heart disease (IHD). Data of these studies indicate that Energostimâ added to traditional treatment of IHD even in short-term regime produced significant reduction in low-density lipoprotein (LDL) cholesterol (_12%), triglycerides (-18%), the ratio of low to high density lipoprotein cholesterol (-29%) and as much important prevented the progression of LDL oxidative modification. The content of the generation of thiobarbituric acid-reactive substances under treatment with Energostimâ was also reduced. The positive changes in atherosclerosis induced factors under treatment with Energostimâ is explained by Energostim's powerful antioxidative properties.

Key words: ischemic heart disease, lipoprotein, peroxidation, energostim.


Experimental Medicine

I. Meskhishvili

The Effect of Acute Moderate Alcohol Ingestion on the Rabbit's Heart Rate Variability

Presented by Member of the Academy Nadareishvili, June 26, 2001

Abstract. The main time domain and the frequency domain parameters trends of heart rate variability (HRV) were studied in rabbits 1/2-3h and 24h after the intragastral administration of a small (moderate) dose of the so-called Pharm-alcohol (40% solution of ethanol 0.5g/kg). Despite the two initial quite diverse vago-sympathetic and emotional -motivational tension, the administration of Pharm-alcohol in two groups was shown to cause during 1-3h the statistically significant changes virtually of all main HRV parameters, which strongly indicate the enhancement of the parasympathetic tone of the vegetative nervous system, while after 24h, only a high frequency normalized index of the spectrum is increased (P<0.01). At the same time, similarly appears obvious the balancing ("normalizing") effect of Pharm-alcohol on the heart rate.

Key words: alcohol, Pharm-alcohol, heart rate variability, rabbit.

Experimental Medicine


A. Mtskhvetadze, A. Mukhadze

Activity of Some Proliferating Factors in Normal and Tumor Cells in Intact State and Following the Ionizing Radiation

Presented by Member of the Academy K. Nadareishvili, June, 5, 2001

Abstract. The main feature of malignant tumor is an unrestrained growth. It is known that growth factors affect an active transport of sodium, potassium, and calcium. Therefore, the volume of active transport may be used as a criterion of impact of certain growth factor. The aim of the present work was: to investigate transmembrane transfer of K+, Na+ and Ca2+ and the ATPase activity in cell cultures in both intact state and under the influence of the growth factors (TGF, EGF, IGF), in comparison with the same indices of the tumor cells; to conduct the same experiments after the action of ionizing radiation. Our experiments have shown that TGF, at a higher extent than EGF and IGF, especially by the criteria of impact on the calcium transport, elicits changes in the ZTZ cells, which resemble indices observed in the tumor cells in Sarcoma-37. This notion is corroborated by the action of ionizing radiation of 500rd as well.

Key words: ionizing radiation, ionic transport, malignization, growth factors.


Experimental Medicine


M. Balavadze, M. Akhvlediani, D. Gachechiladze

Effects of Prolonged (one-year) Hypolipidemic Therapy upon Lipid Spectrum Parameters and Intima-Media Thickness of Carotid Arteries

Presented by Member of the Academy F. Todua, December 28, 2001

Abstract. 210 patients with hypercholesterolemia underwent 1-year treatment with hypolipidemic drugs (Atorvastatin, Orlistat). The correlation of intima-media thickness (IMT) of carotid arteries with the value of total cholesterol has been established. The hypolipidemic therapy stabilizes carotid arteries IMT. Orlistat has more effective influence upon triglycerides and contributes to the normalization of their number. Atorvastatin treatment shows, that along with complete normalization of the number of total cholesterol, lipid antiatherogenic fraction i.e. high density lipoprotein cholesterol increased, low density lipoprotein cholesterol decreased.

Key words: hypolipidemic therapy, intima-media thickness.


Experimental Medicine


I. Mikadze, G. Abzianidze

Behavior of Endothelial Cells in Vitro Conditions

Presented by Member of the Academy N. Javakhishvili, January 22, 2002

ņbstract. The attachment and growth of human endothelial cells (EC) on Petri dishes and on the surface of vascular transplants were investigated. Petri dishes were covered with citrate human plasma, serum of human blood and gelatin of the firm Sigma, USA. The EC were plated at 4.0ī103 cells/cm2 and were fixed after 5, 10, 15, 30, 60 min of cultivation to be prepared for scanning electronic microscopy. The investigated xenobioprostheses, alloprosthesis from the human umbilical cord vein, prostheses from PTFE, dacron, fluorlonlavsane were treated with fibronectin, collagen.

Key words: endothelial cells, phyllopodium, lamellipodium, lamelloplasma, vascular prostheses endothelialization.


Experimental Medicine


A. Melia, Z. Klimiashvili, N. Salibegashvili, I. Kavadze, G. Sukoian,

Corr. Member of the Academy N. Karsanov

Beneficial Action of Refracterin on the Exercise Tolerance in Patients with Severe Form of Chronic Heart Failure

Presented December 26, 2001

Abstract. In 63 patients with chronic heart failure, mean NYHA III functional class, it has been shown that replacement of digoxin by Refrakterin (containing b-acetyldigoxin) with pronounced antiischemic and antihypoxic properties in the conventional therapy of CHF leads to significant improvement of systolic function and CHF symptoms not only at rest but during exercises too. Functional capacity in CHF patients may highly improve even over short period of treatment with Refrakterinâ. There was a strong univariate association between the distance ambulated during 6 min walk test and redox-potential (r=0.81, p<0.001) and multivariate association between the distance ambulated during 6 min walk test from the one side and redox-potential and concentration of plasma norepinephrine from the other (R 6.1, p<0.0001). Moreover, it has been shown the correlation between the change in ejection fraction of left ventricle before and after 6 min exercise and NAD/NAD◊H (r=0.67, p<0.01) and NADP/NADP◊H (r=0.72, p<0.01) in Refrakterinâ treated group.

Key words: chronic heart failure, Refrakterin, sympatho-adrenal system, exersice tolerance.


Experimental Medicine

A.Chkhotua, A.Altimari, E.Gabusi, A.D'Errico, Member of the Academy L.Managadze, M.Yakubovich, J.Vienken, S.Stefoni, P.Chieco, A.Yussim, W.F.Grigioni

Chronic Allograft Nephropathy is Associated with Increased Expression of p21(WAF1/CIP1) CDK Inhibitor Gene Correlating with the Grade of Nephropathy and the Number of Acute Rejections

Presented February 12, 2002

Abstract. Statement of p21(WAF1/CIP1)CDK inhibitor gene was analyzed in 14 normal human kidney tissues of different age and 9 chronically rejected kidney grafts. All normal kidneys independently of patient's age were negative for p21 statement, whereas glomerular, tubular and interstitial statement of the marker was detected in 88% and vascular statement in 66.7% of chronically rejected kidneys (p<0.0001 and 0.001 respectively). No correlation was found between the intensity of p21 statement and: recipient age, donor age and number of HLA mismatches. Marker was higher expressed in grade 3 than in grade 2 of AN (p=0.059 for glomerular score). Tubular statement of p21 was correlated with the number of acute rejections: p<0.05 when 3 vs. 1,2 and p=0.0046 when 3 vs. 0 episodes of previous acute rejections. This is the first report on the absence of p21 statement in normal human kidneys of different age and its up regulation in CAN.

Key words: nephropathy, p21(WAF1/CIP1) cyclin dependent kinase (CDK) inhibitor gene, cellular senescence marker, renal allograft rejection

Experimental medicine

N. Gordadze

Farmorubicin and Conduction System of Heart

Presented by Member of the Academy N. Javakhishvili, December 26, 2001

Abstract. The influence of farmorubicin on conduction system of rat,s heart was investigated by electron mycroscopy, electron hystochemistry and ECG.

The 0.8 mg of farmorubicin was injected intraperitoneally twice a week, every other day. 6 courses with three week interval were created. Colloid and ionized lanthanum were used for verification of reversibility of cell damage.

The first course of farmorubicin produced in rat conduction system acute changes of microcirculatory vessels. Mainly pacemaker cells in S-A and A-V nodes were damaged; next courses of farmorubicin revealed cumulative long-term cardiotoxic effect. Latent pacemaker and Purkinje cells undergo calcium-type injury - contractions of sarcomeres, hydratation of sarcoplasmic reticulum, electron-dense inclusions in mitochondrial intercristal areas.

Key words: farmorubicin, cardiotoxicity, conduction system of heart.


Experimental medicine

K. Robakidze

Interdependence of Etiologic Agents of Staphyloderma - the Coagulation Activity and Stability to Antibiotics

Presented by Member of the Academy T. Chanishvili, December 6, 2001

Abstract. The interdependence of etiologic agents of staphyloderma, namely, the coagulation activity and the degree of resistance to antibiotics has been studied. The direct correlation between these two agents has been established - the majority of antibiotic-resistant strains was coagulase-positive.

Key words: staphyloderma, etiologic agent, enzyme coagulase, resistance to antibiotics.




D. Kakhiani

Difficulties of Learning Process in Children with Attention Deficit Hyperactivity Disorder

Presented by Member of the Academy Sh. Nadirashvili, December 28, 2001

Abstract. We have studied the intellectual abilities of ADHD children in the context of their academic achievement. The WISC-R was performed to 75 children with ADHD and 40 children from the control group. There was significant difference in difficulties in the learning process according to the teachers' assessment of the ADHD children. The obtained results evidence that though the ADHD children's IQ levels are within the norm, they have serious problems in learning process which tend to become more severe with the growth.

Key words: attention deficit, hyperactivity disorder.



T. Babunashvili

Economic Growth Factors and Industrial Reserves in Georgia

Presented by Corr. Member of the Academy A. Silagadze December 28, 2001

Abstract. Recommendations for Georgian industry development such as population income rate, Government expenditure rate, investments and level of foreign inquiry for production have been analyzed in this work.

All the above directions can be used by the government for realization of the accepted industrial conceptions and strategic development of separate industrial fields.

In order to get drastic acceleration of industry development, it is necessary to activate innovation politics using existing technological equipment.

Key words: acceleration of economic development.




P. Bolashvili

Prospects for Decentralizing Municipal Management System in Georgia

Presented by Corr. Member of the Academy L. Chikava, January 14, 2002

Abstract. The role and prospects of management system decentralization in transitional period are discussed. The justification is given that in the conditions of appropriate planning and correct guidance the decentralization of municipal management system in Georgia can bring positive results and provide for the successful solution of many important social-economic problems.

Key words: decentralization, management, equity, economic growth.




L. Kokiauri

The Problems of Promotion of Small Business Investment in Georgia

Presented by Corr. Member of the Academy L. Chikava, January 13, 2002

Abstract. The study of the tendencies of small and medium business development in Georgia shows that this sphere of economics is open for investment and further development. The effective ways of financing and investment support of small and medium business in which major organizing part belongs to the state should be realized.

Key words: small and medium business, investment.



G. Tsaava

Social and Economic Consequences of the Formation of

Financial-Credit System

Presented by Corr. Member of the Academy L. Chikava, December 18, 2001

Abstract. Unsuccessful situation in the economics of Georgia in the stage of implantation of market methods of regulation and structural modification of national economy has been reflected on formation and operation of financial-credit system of the country. Special role in transition to economy of market type of banking system as stabilizer of economic processes at the expense of implementation of inter-regional and interbranch reallocation of the money capital is noted.

Key words: financial-credit system.




L. Grigalashvili

On the Problems of Accounting Reform in Transition Period

Presented by Corr.Member of the Academy A.Silagadze, March 28, 2002

Abstract. In present paper, we consider the problems of accounting and reporting reform in transition period. A new role of accounting in transition period to market economy is underlined. Accounting systems (patterns) and regulating authorities of different countries are considered. The necessity of the formation of accounting system in accordance with the international standards is justified. Concrete measures for acceleration of accounting and reporting system are proposed.

Key words: accounting, reporting , transition period.



T. Gamsakhurdia

The Ways of Improvement of Budgetary System in Georgia

Presented by Corr. Member of the Academy A. Silagadze, march 7, 2002

Abstract. Main problems of tax and budgetary system in Georgia have been analyzed. New ways of improvement of Tax and Budgetary system on the experience of the developed countries have been offered. The results of the investigations can be used for the stabilization of national currency and creation new jobs for population.

Key words: tax income, budget, program financing.




A. Sulaberidze, N. Gerzmava

Importance of the Family Planning and Reproductive Behaviour Issues in the Transition Period

Presented by Corr. Member of the Academy L.Chikava, December 18, 2001

Abstract. The article reviews obvious changes concerning reproductive behaviour in Georgia, based on the statistical and social surveys. It discusses the tendency and reasons of abortion prevalence over any other methods of contraception.

Key words: abortion, family planning.



O. Sekerci

Character Selection in Ibsen's "A Doll's House"

Presented by Member of the Academy G. Tsitsishvili, December 26, 2001

Abstract. Premise and character are necessities in all good literary writing. Without premise, it is almost impossible for a writer to know his characters. Every character represents a world of his own. Ibsen's character stands revealed through conflict; conflict begins with decision; decision is made because of the premise of his play. Ibsen's characters are always tridimensional characters. Tridimensional characters always grow. Ibsen had a clear cut premise which was eager to prove, his character had to be tridimensional people who could stand alone without the author's help.

Key words: Premise, tridimensional characters, Ibsen.




M.Antidze, George P. Tumanishvili

Time in Shakespeare's Tragedy "Romeo and Juliet"

Presented by Corr.Member of the Academy A.Gvakharia, April 2, 2002

Abstract. Shakespeare uses the notion of `time' as a constructive component equally taking part in general construction of the literary work which makes the actions of the characters truthful with clear psychological motivation. In construction of the drama "Romeo and Juliet" the theme of Time is used as a four dimensional coordinate. The interpretation of the drama is possible only with account of four-dimensionality of its construction.

Key words: time, Shakespeare.




George P. Tumanishvili

Hedonistic Motif in Literature

Presented by Corr.Member of the Academy A.Gvakharia, April 2, 2002.

Abstract. The evolutionary process of the development of hedonistic motif was considered. The quantitative change that hedonistic motif has undergone in time interval from the Roman Empire to the Renaissance lies in the plane of perception of eroticism as such. The evolution of the motif happens in the mental plane rather than in the plane of revaluation of psychomotivations of hedonism as psychic phenomenon.

Key words: hedonism, motif.